GPR119 and GPR131: Functional Difference?
نویسندگان
چکیده
Diabetes mellitus (DM) is known as metabolic disorders showing hyperglycemia and hyperlipidemia due to the dysfunction of pancreatic islets [1]. The prevalence of DM in clinics is markedly increased and it will reach approximately 439 million in 2030 [2]. Generally, DM is mentioned to include two main subtypes, Type 1 (Insulin dependent diabetes) and Type 2 (Non-insulin dependent diabetes) subtypes, in addition to others. Clinically, type 2 DM (T2DM) characterized by insulin resistance in addition to hyperglycemia and/or hyperlipidemia is widely considered as metabolic disorder [3]. Many factors, such as reduced insulin secretion from pancreatic dysfunction, inadequate hepatic glucose production and peripheral insulin resistance, are introduced to involve in the development of T2DM [4]. Therefore, therapeutic approaches have been the hot projects to develop critically.
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